No consensus yet exists on how to handle incidental fnd-ings in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are fndings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers (...) have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. (shrink)

Hypocretin regulates brain reward function and cocaine consumption in rats. The hypocretinergic (Hcrt) system is implicated in energy homeostasis, feeding and sleep regulation. Hypocretinergic cell bodies are located in the lateral hypothalamus (LH) and project throughout the brain. The aim of the present studies was to investigate the role of the Hcrt system in regulating brain reward function and the reinforcing properties of cocaine in rats. Intracranial self-stimulation (ICSS) thresholds provide an accurate measure of brain reward function in rats. Here (...) we show that a single injection of Hcrt-1 (5 µg icv) induced persistent, long-lasting elevations in ICSS thresholds in drug-naïve rats. Indeed, Hrct-1 elevated ICSS thresholds for 36 h, with peak elevations between 6 and 12 hours after injection. Hrct-1-induced threshold elevations were attenuated by an antibody known to neutralize the binding of hcrt-1 to its receptors. Taken together, these observations suggest that Hrct-1 negatively regulates brain reward function in rats. Because Hrct-1 negatively regulates brain reward function, we hypothesized that it may attenuate the increased brain reward function usually observed after cocaine consumption, and thereby alter cocaine self-administration behavior. A daily injection of Hrct-1 (1 µg icv), for 4 consecutive days, slightly increased cocaine self-administration (0.25 mg/infusion) in rats. Overall, these data demonstrate that Hrct-1 negatively regulates brain reward function, and as such may indirectly alter cocaine self-administration. Given the well-established role of hypocretin neurons in regulating feeding behavior and sleep, we hypothesize that hypocretinergic regulation of brain reward function may provide a mechanism by which appropriate and competing behaviors (e.g. sleep or feeding) may be engaged to maintain energy homeostasis. (shrink)

The first English translation of Fichte’s second set of 1804 lectures on the Wissenschaftslehre.

Current evolutionary and cognitive theories of religion posit that supernatural agent concepts emerge from cognitive systems such as theory of mind and social cognition. Some argue that these concepts evolved to maintain social order by minimizing antisocial behavior. If these theories are correct, then people should process information about supernatural agents’ socially strategic knowledge more quickly than non-strategic knowledge. Furthermore, agents’ knowledge of immoral and uncooperative social behaviors should be especially accessible to people. To examine these hypotheses, we measured response-times (...) to questions about the knowledge attributed to four different agents—God, Santa Claus, a fictional surveillance government, and omniscient but non-interfering aliens—that vary in their omniscience, moral concern, ability to punish, and how supernatural they are. As anticipated, participants respond more quickly to questions about agents’ socially strategic knowledge than non-strategic knowledge, but only when agents are able to punish. (shrink)

A semantics for quantified modal logic is presented that is based on Kleene's notion of realizability. This semantics generalizes Flagg's 1985 construction of a model of a modal version of Church's Thesis and first-order arithmetic. While the bulk of the paper is devoted to developing the details of the semantics, to illustrate the scope of this approach, we show that the construction produces (i) a model of a modal version of Church's Thesis and a variant of a modal set theory (...) due to Goodman and Scedrov, (ii) a model of a modal version of Troelstra's generalized continuity principle together with a fragment of second-order arithmetic, and (iii) a model based on Scott's graph model (for the untyped lambda calculus) which witnesses the failure of the stability of non-identity. (shrink)

Benjamin G. Cook, Ibn Sabʿîn and Islamic Orthodoxy: A Reassessment.

ABSTRACTDepression is associated with increased emotional response to stress. This is especially the case during the developmental period of adolescence. Cognitive reappraisal is an effective emotion regulation strategy that has been shown to reduce the impact of emotional response on psychopathology. However, less is known about whether cognitive reappraisal impacts the relationship between depressive symptoms and emotional responses, and whether its effects are specific to emotional reactivity or emotional recovery. The current study examined whether cognitive reappraisal moderated the relationship between (...) depressive symptoms and trait or state measures of emotional reactivity and recovery. A community sample of 127 adolescents, at an age of risk for depression, completed self-report measures of trait emotional responding and depressive symptoms. In addition, they completed an in vivo social stress task and were assessed on state emotional reactivity and recove... (shrink)

Sensation elicited by a skin stimulus was subjectively reported to feel stronger when followed by a stimulus to somatosensory cerebral cortex , even when C was delayed by up to 400 ms or more. This expands the potentiality for retroactive effects beyond that previously known as backward masking. It also demonstrates that the content of a sensory experience can be altered by another cerebral input introduced after the sensory signal arrives at the cortex. The long effective S-C intervals support the (...) thesis that a duration of cortical activity of up to 0.5 s is required before awareness of a sensory stimulus is developed. (shrink)

Through an engagement with Sylvia Wynter, this article explores how black feminist critiques of the human can inform critical genealogies of religion. Specifically, the article develops a theoretical framework to interrogate how the modern construction of religion and the secular also produces racial identities and hierarchies. To draw attention to the global dimensions of this project, the article foregrounds the seminal work of Jason Ā. Josephson-Storm in his book, The Invention of Religion in Japan. The article argues that studies like (...) Josephson-Storm's show how religion helps transform existing forms of social organization within a bio-evolutionary conception of the nation, and is used by the state to differentiate between who can be considered fully human and who cannot. In this process “superstition” or “irrationality” is rewritten as a biological threat to the health and well-being of “the people,” and political domination is represented as a struggle to purify the nation. (shrink)

The gradual secularization of European society and culture is often said to characterize the development of the modern world, and the early Italian humanists played a pioneering role in this process. Here Benjamin G. Kohl and Ronald G. Witt, with Elizabeth B. Welles, have edited and translated seven primary texts that shed important light on the subject of "civic humanism" in the Renaissance.Included is a treatise of Francesco Petrarca on government, two representative letters from Coluccio Salutati, Leonardo Bruni's panegyric (...) to Florence, Francesco Barbaro's letter on "wifely" duty, Poggio Bracciolini's dialogue on avarice, and Angelo Poliziano's vivid history of the Pazzi conspiracy. Each translation is prefaced by an essay on the author and a short bibliography. The substantial introductory essay offers a concise, balanced summary of the historiographcal issues connected with the period. (shrink)

We show that the actuality operator A is redundant in any propositional modal logic characterized by a class of Kripke models (respectively, neighborhood models). Specifically, we prove that for every formula ${\phi}$ in the propositional modal language with A, there is a formula ${\psi}$ not containing A such that ${\phi}$ and ${\psi}$ are materially equivalent at the actual world in every Kripke model (respectively, neighborhood model). Inspection of the proofs leads to corresponding proof-theoretic results concerning the eliminability of the actuality (...) operator in the actuality extension of any normal propositional modal logic and of any “classical” modal logic. As an application, we provide an alternative proof of a result of Williamson’s to the effect that the compound operator A□ behaves, in any normal logic between T and S5, like the simple necessity operator □ in S5. (shrink)

This fascinating and timely volume explores current thinking on vital topics in moral psychology, spanning the diverse disciplines that contribute to the field. Academics from cognitive science, evolutionary biology, anthropology, philosophy, and political science address ongoing and emerging questions aimed at understanding the thought processes and behaviors that underlie our moral codes-and our transgressions. Cross-cutting themes speak to individual, interpersonal, and collective morality in such areas as the development of ethical behavior, responses to violations of rules, moral judgments in the (...) larger discourse, and universal versus specific norms. This wide-angle perspective also highlights the implications of moral psychology research for policy and justice, with cogent viewpoints from: Philosophy: empiricism and normative questions, moral relativism. Evolutionary biology: theories of how altruism and moral behavior evolved. Anthropology: common moral values seen in ethnographies from different countries. Cognitive and neural sciences: computational models of moral systems and decision-making. Political science: politics, governance, and moral values in the public sphere. Advice on moral psychology research-and thoughts about its future-from prominent scholars. With the goal of providing a truly multidisciplinary forum for moral psychology, this volume is sure to spark conversations across disciplines and advance the field as a whole. Sampling the breadth and depth of an equally expansive and transformative field, Moral Psychology: A Multidisciplinary Guide will find an engaged audience among psychologists, philosophers, evolutionary biologists, anthropologists, political scientists, neuroscientists, lawyers, and policymakers, as well as a more general audience interested better understanding the complexity of moral psychology research. (shrink)

Le visage est-il un phénomène simple ou complexe? Serait-il juste de le définir comme cet aspect de l’être humain qui dépasse tout effort de compréhension et de totalisation, ou bien y a-t-il d’autres caractéristiques de ce phénomène qu’il faut inclure dans toute définition ou description du visage? Le visage est un événement fondamental. Parmi les multiples manières d’approcher l’être, de se rapporter...

Drawing from a multi-sourced data corpus gathered from high-net-worth social media influencers, this article explores how these individuals reconcile ethicality and living a luxury lifestyle through the enactment of three types of personas on Instagram: Ambassador of ‘True’ Luxury, Altruist, and ‘Good’ Role Model. By applying the concepts of taste regimes and social moral licensing, we find that HNW social media influencers conspicuously enact and display ethicality, thereby retaining legitimacy in the field of luxury consumption. As these individuals are highly (...) influential, they could leave a potentially significant mark on public discourse and, consequently, on their audiences’ construction of ethically responsible luxury consumption. In this vein, this article offers significant managerial insights into professional influencers and discusses ethical managerial practices to ensure ethical collaborations between influencers and managers. (shrink)

Im Zentrum des vorliegenden Sammelbandes steht die Frage nach dem Bösen in Religionen, die als monotheistisch verstanden werden oder für die zumindest die Herrschaft des Hauptgottes über alle anderen Götter und Mächte ein entscheidendes Anliegen ist. Der Schwerpunkt liegt auf dem sich formierenden Judentum und Christentum sowie dem Alten Testament. Besonderes Interesse gilt den Texten aus Qumran, und darüber hinaus erfolgt ein Blick auf mittelalterliche Heiligenlegenden. Die Beiträge des Bandes zeigen, dass es in den antiken jüdischen und christlichen Texte eine (...) große Vielfalt von Verkörperungen des Bösen gibt, sei es extern als Dämon oder Teufel, sei es intern als die menschliche Fähigkeit, Böses zu tun. Außerdem stellt sich heraus, dass in der jüdisch-christlichen Literatur Dualismus nicht grundsätzlich abgelehnt wird, aber nur Formen von Dualismus vorkommen, in denen das Böse Gott und dem Guten letztlich untergeordnet ist. Mit Beiträgen von: Jörn Bockmann, Miryam T. Brand, Jan Dochhorn, Matthew Goff, Erkki Koskenniemi, Michael Morris, Hector M. Patmore, Susanne Rudnig-Zelt, Markus Saur, Ryan E. Stokes, Oda Wischmeyer, Benjamin Wold. (shrink)

The study examined the influence of the Pond Report on the teaching of medical ethics in the London medical schools. A questionnaire was given to both medical students and college officers. All medical colleges reported that ethics was included in the curriculum. However, from students' replies, it seems that attendance of optional courses is low and that not all current final year medical students have had any formal teaching in medical ethics. Stronger guidelines are necessary to ensure appropriate ethical training (...) in London medical schools. (shrink)

Mental health professionals rightfully experience significant anxiety regarding their duty to protect when working with potentially dangerous individuals. This work dispels myths and provides readers with a resource addressing the situations where a duty to protect may apply.

American Academy of Pediatrics (AAP) and American College of Medical Genetics (ACMG) recently provided two recommendations about predictive genetic testing of children. The Clinical Sequencing Exploratory Research Consortium's Pediatrics Working Group compared these recommendations, focusing on operational and ethical issues specific to decision making for children. Content analysis of the statements addresses two issues: (1) how these recommendations characterize and analyze locus of decision making, as well as the risks and benefits of testing, and (2) whether the guidelines conflict or (...) come to different but compatible conclusions because they consider different testing scenarios. These statements differ in ethically significant ways. AAP/ACMG analyzes risks and benefits using best interests of the child and recommends that, absent ameliorative interventions available during childhood, clinicians should generally decline to order testing. Parents authorize focused tests. ACMG analyzes risks and benefits using the interests of the child and other family members and recommends that sequencing results be examined for additional variants that can lead to ameliorative interventions, regardless of age, which laboratories should report to clinicians who should contextualize the results. Parents must accept additional analysis. The ethical arguments in these statements appear to be in tension with each other. (shrink)

_Zettel, _ an en face bilingual edition, collects fragments from Wittgenstein's work between 1929 and 1948 on issues of the mind, mathematics, and language.